4-Hydroxy-6-alkyl-2-pyrones as nucleophilic coupling partners in Mitsunobu reactions and oxa-Michael additions

Poly (vinylpyrrolidone)-Grafted Silica as a Polymeric Cosolvent Catalyst for Organic Transformations in Organic and Aqueous Media

Poly (vinylpyrrolidone)-grafted silica as an organic-inorganic hybrid material was used as an effective heterogeneous polymeric cosolvent catalyst in organic reactions. This modified silica catalyzed nucleophilic displacement of alkyl halides for easy preparation of alkyl thiocyanates, alkyl cyanides, alkyl azides and alkyl aryl ethers. Furthermore, the catalyst was applied for the conversion o...

Calcium Chloride catalyzed Intramolecular Oxa Michael addition of 2’-Hydroxychalcone to Flavanone

An efficient cyclization of 2’-hydroxychalcone to flavanone using calcium chloride as a catalyst was developed. The scope of the reaction was studied with substituted 2’-hydroxychalcone and these chalcones was converted into corresponding flavanone in good yield. The merits of this method are inexpensive and easily available catalyst, easy workup procedure, avoid use of toxic solvent

Oxidative Arylation

The addition of aryl groups to unactivated olefins represents a direct approach to C!C bond construction. Pd-catalyzed coupling of aryl halides with alkenes, the Heck reaction, offers a viable approach to arylation. However, terminal unactivated olefins often display low reactivity in Heck reactions and can yield mixtures of styrenes and allyl arenes owing to poor regiocontrol in the b-hydride ...

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00675f Click here for additional data file.

Uncatalyzed Synthesis of Arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in Hot Water by Domino Knoevenagel/Michael Reactions

A simple and ecofriendly method was developed for the synthesis of arylmethylene[bis(5,5- dimethyl-3-hydroxy-2-cyclohexene-1-ones)] from the reaction of 5,5-dimethylcyclohexane- 1,3-dione and aromatic aldehydes in an aqueous media without any catalyst via Knoevenagel condensation followed by rapid Michael addition. No cyclization product was down to convert these enolic forms to xanthene deriva...